CHEM 455 - Introduction to Biomedicinal Chemistry

(3.00)

A survey of principles and methods of drug design, including modern rational approach aided by computers, disease models, natural products, analogue synthesis and pharmacophore identification; physicochemical principles of drug action, including solubility, partition coeffeicents, surface interactions, stereochemical, electronic and quantum chemical factors, chemical bonding and quantitative structure-activity relationships (QSAR); receptor concept of drug action, including nature, definition, characterization, models and classical theories of receptor function; mechanisms of drug action, including development, inhibition and regulation; drug distribution, metabolism and inactivation, including bioavailability, biotransformations, chemical and metabolic stability, pharmacokinetic variability and design of prodrugs; case studies selected from a list of antitumor, analgetic, antimicrobial, anticholinergic, antiadrenergic, psychoactive and cardiovascular drugs; and current status of and future impact on drug development, including protein therapeutics, gene therapy, antisense drugs, cytokines and drug resistance.

Components: Lecture
Requirement Group: You must complete CHEM 352 with a grade of C or better