Mar 29, 2024  
2017-2018 Graduate Catalog 
    
2017-2018 Graduate Catalog [ARCHIVED CATALOG]

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CHEM 653 - Organic Chemistry of Nucleic Acids

[3]
A survey of organic chemical principles governing structure, properties and reactions of nucleic acids, including synthesis of nucleic acid bases, nucleosides, nucleotides and poly-nucleotides and their important synthetic analogs possessing anti-viral and anti-tumor properties. Study of reactivity of nucleic acid building blocks, including addition and substitution reactions, ring openings and rearrangements, hydrolysis of glycosidic and phosphodiester bonds and photochemical reactions. Study of primary structure, acid-base property, tautomerism and conformation of nucleic acids. Review of secondary structure, base-pairing and stacking interactions, helical structure, stability, conformation, denaturation, renaturation and cross-linking.
Prerequisite: Prerequisite: Consent of instructor.



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