BTEC 658 - Principles of Downstream Bioprocessing

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BTEC 658 is a comprehensive study of fundamentals of downstream processing for biochemical products recovery and formulation. Specifically focuses on purification process design and optimization to separate, concentrate and recover a desired product (enzymes, chemicals, pharmaceuticals, novel protein constructs) for its intended use. Integration of innovation in process development, scale-up and facility fit, and commercial process goals under good manufacturing practices is also presented using case studies and publications form reliable sources.
Topic areas to be discussed include: (1) learning traditional unit operations, new concepts and emerging technology and their benefits to biochemical product recovery (principles of centrifugation, chromatography, filtration, membrane processes, introduction to continuous processing); (2) assessing the impact of change in unit operations on the process and product quality attributes; (3) examining analytical and process validation issues that are critical to successful manufacturing in large scale a high-purity and high-quality protein; (4) addressing strategy on formulation development and stability; and (5) highlighting validation and regulatory concerns related to downstream process implementation.
Course ID: 102462
Prerequisite: BTEC 675
Components: Lecture
Grading Method: R