CHEM 672 - Enzyme Reaction Mechanisms

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The mechanism of enzyme action will be examined, with emphasis on the following topics: three-dimensional structure of enzymes, chemical catalysis, methods of determining enzyme mechanisms, sterochemistry of enzymatic reactions, detection of intermediates, affinity labels and suicide inhibitors, transition state analogs, energy relationships, evolutionarily “perfect” enzymes, genetic engineering and enzymes and use of binding energy in catalysis. Instruction will be in both lecture and seminar format, with emphasis on recent literature.
Prerequisite: Prerequisites: CHEM 437 or consent of instructor.
Note: CHEM 651 recommended.