STAT 619 - Biostatistics: Principles and Design

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Philosophy and statistical theory involved in designing sequential, randomized medical studies, particularly, clinical trials; Scientific method; randomization principle; randomization techniques and their associated distribution theory and permutation tests; adaptive designs and ethics behind randomized studies involving human subjects; statistical methods, including survival analysis, power and sample size; dealing with multiplicities; interim monitoring techniques, including conditional power, spending functions and Brownian motion; randomized does-response studies; likelihoods and introductory Martingale theory. Both theory and applications will be stressed.
Prerequisite: Prerequisite: STAT 601, STAT 453 or consent of instructor.