CHEM 453 - Organic Chemistry of Nucleic Acids (3)

A survey of organic chemical principles governing structure, properties and reactions of nucleic acids, including synthesis of nucleic acid bases, nucleosides, nucleotides and polynucleotides, and their important synthetic analogs possessing antiviral and antitumor properties. Study of reactivity of nucleic acid building blocks, including addition and substitution reaction, ring-openings and rearrangements, hydrolysis of glycosidic and phosphodiester bonds, and photochemical reactions. Study of primary structure, acid-base property, tautomerism and conformation of nucleic acids. Review of secondary structure, base-pairing and -stacking interactions, helical structure, stability, conformation, denaturation, renaturation and cross-linking.

Grading: Graded/Satisfactory Unsatisfactory/Audit
Course ID: 52729
Consent: No Special Consent Required
Components: Lecture
Prerequisite: CHEM 352 with a grade of ‘C’ or better.