CHEM 653 - Organic Chemistry of Nucleic Acids

Credits: [3]

Description: A survey of organic chemical principles governing structure, properties and reactions of nucleic acids, including synthesis of nucleic acid bases, nucleosides, nucleotides and poly-nucleotides and their important synthetic analogs possessing anti-viral and anti-tumor properties. Study of reactivity of nucleic acid building blocks, including addition and substitution reactions, ring openings and rearrangements, hydrolysis of glycosidic and phosphodiester bonds and photochemical reactions. Study of primary structure, acid-base property, tautomerism and conformation of nucleic acids. Review of secondary structure, base-pairing and stacking interactions, helical structure, stability, conformation, denaturation, renaturation and cross-linking.
Course ID: 052763
Prerequisite: Prerequisite: Consent of instructor.
Components: Lecture
Grading Method: A-F, Pass/Fail, Audit