CHEM 455 - Introduction to Biomedicinal Chemistry

(3.00)

A survey of the drug design, discovery and development processes utilized by academic and industrial medicinal chemists using rational approaches to drug design and development from a biological, organic chemistry and mechanistic standpoint. Topics will include: structure activity relationship studies (SAR), identification of the pharmacophore, stereochemical considerations, the role of electronic and H-bonding interactions, bioavailability, +chemical and metabolic stability, toxicity, drug metabolism, DNA interactive drugs, receptors and enzymes as drug targets, the design and mechanistic features of receptor and enzyme inhibitors and the pharmacokinetic variability and design of prodrugs, the advantages and disadvantages of using monotherapy vs combination therapies such as multitargeted drugs, dual inhibitors and mutual prodrugs, among other current approaches to drug design. Additional topics will include the use of computers in drug design, the development of resistance, use of synergism in multidrug therapy, clinical trials, patent issues as well as moral and ethical responsibilities facing medicinal chemists. Case studies will focus on currently used (or recently used, but discontinued) drugs, particularly those reflecting controversy or innovation, as well as historical perspectives.

Course ID: 52730
Consent: No Special Consent Required
Components: Lecture
Prerequisite/Corequisite: You must complete CHEM 352 with a grade of C or better